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One example is, extreme activation of CaMKII is usually characterized by enhanced activity of Ca2+ channel gating, leakage of Ca2+ from sarcoplasmic reticulum, and dysregulation of Ca2+ homeostasis, which can jointly lead to arrhythmia and heart failure. Hashimoto et al. Owing to the importance of the indole like a scaffold https://claytonzriym.blogunteer.com/30657548/indazole-uses-secrets

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