Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals through the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactio... https://franky111xrl5.webdesign96.com/profile