SSRI/SNRI Antidepressants: May well appreciably lower or block psilocybin effects resulting from serotonin receptor Competitiveness. Remedies like sertraline, fluoxetine, or venlafaxine can diminish the experience Euphoria and laughter: A robust uplift in temper, with waves of contentment and giggling fits. Many describe a “coronary heart-opening” sensation of affection or empathy. http://